Investigating biological activity spectrum for novel styrylquinazoline analogues.

نویسندگان

  • Josef Jampilek
  • Robert Musiol
  • Jacek Finster
  • Matus Pesko
  • James Carroll
  • Katarina Kralova
  • Marcela Vejsova
  • Jim O'Mahony
  • Aidan Coffey
  • Jiri Dohnal
  • Jaroslaw Polanski
چکیده

In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds.

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عنوان ژورنال:
  • Molecules

دوره 14 10  شماره 

صفحات  -

تاریخ انتشار 2009